Further studies on the pathogenesis of ovarian tumors in mice.

The formation of granulosa-cell tumors and subcutaneous tissues or testes of intact and cas luteomas in intrasplenic ovarian grafts in castrated trated mice did not readily become tumorous. rats (1) and in intrasplenic and intrapancreatic The present experiments are concerned with the ovarian grafts in castrated male and female mice influence of gonadal and gonadotrophic hormones has been reported previously (6—9).These experiin the development of tumors in intrasplenic ovar ments were based on two principles : (a) the capaian grafts in castrated mice. The purpose of the in bility of the liver to inactivate ovarian hormones vestigation was to obtain additional evidence on when the hormones circulate through the hepatic the possible role of gonadotrophic hormones in the portal system and (b) the increase of pituitary genesis of ovarian tumors.